Test Detail
Understanding the Test
Test Measures
FAQ's
References
Other Tests
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Dr. Shreya Gupta
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Antenatal Profile

Also known as Prenatal testing, Prenatal profile
Antenatal Profile Includes 46 testsView All
You need to provide
Blood, Urine
This test is for
Female
Test Preparation
  1. Overnight fasting (8-12 hrs) is required. Do not eat or drink anything except water before the test.
  2. The urine sample must preferably be the first-morning midstream urine (part of urine that comes after the first and before the last stream). Collect the urine sample in a sealed and sterile screw-capped container provided by our sample collection professional. Ensure that the urethral area (from where the urine is passed) is clean & the container doesn't come in contact with your skin. Women are advised not to give the sample during the menstrual period unless prescribed.
  3. A duly filled Consent form for HIV testing & Pre-test counselling (Annexure - CR/01) is mandatory.

Understanding Antenatal Profile


What is Antenatal Profile?

An Antenatal Profile is tailored to monitor the health of both the pregnant women and the growing baby. This profile helps in the early detection and management of pregnancy complications, while also assessing the risk of infections, ensuring the well-being of both. 

An Antenatal Profile, also known as prenatal testing comprises a combination of blood and urine tests that are done during pregnancy to evaluate the health status of the mother and the growing baby. This profile is usually done during the first trimester of pregnancy because it allows for early detection and management of any potential pregnancy-related complications allowing for timely intervention and management. 

The tests included in Antenatal Profile, assess factors such as the mother’s overall health, blood picture, immunity status, and risk factors for conditions like gestational diabetes and preeclampsia. The results of the Antenatal Profile guide doctors in providing appropriate medical care and interventions to ensure a healthy pregnancy and safe delivery.

A few special preparations need to be considered before undertaking an Antenatal Profile. However, these preparations may vary depending on the individual test included in this profile. You are required to submit all the samples that are a part of this profile during the sample collection itself. 

Test result ranges are approximate and may differ slightly between labs. Abnormal test results require an expert interpretation, therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for proper understanding of the test results. Based on your test results, your doctor may suggest additional tests or prescribe prenatal vitamins and supplements to support a healthy pregnancy and promote the optimal development of your growing baby.

What is Antenatal Profile used for?

An Antenatal Profile is done:

  • For early detection of potential health problems in both the mother and the growing baby.
  • To assess the risk of infectious diseases, and other pregnancy-related complications.
  • To monitor the health of the mother and the baby throughout the pregnancy.
  • To prepare expectant parents for any potential challenges or health concerns during pregnancy.
  • To facilitate timely management of any identified conditions or abnormalities to optimize pregnancy outcomes.
  • To promote maternal and fetal wellbeing by addressing any existing health problem or risk factors. 

What does Antenatal Profile measure?

Contains 46 tests

An Antenatal Profile, recommended for pregnant women, especially in the first trimester, comprises a series of blood and urine tests to ensure the well-being of the mother and the baby. These tests help detect and manage potential health risks, safeguarding both mother and baby. The profile includes blood tests like complete blood count (CBC), blood group, and Rh factor to check for anemia and Rh factor compatibility. Additionally, screenings for infections like syphilis, HIV, and hepatitis B are conducted to prevent transmission to the baby. It also covers tests for gestational diabetes, thyroid function, and urinary tract infections, ensuring comprehensive prenatal care for a healthy pregnancy. 

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FBS (Fasting Blood Sugar)

A fasting blood sugar test measures the glucose level in the body under overnight fasting conditions. Glucose serves as the body's energy currency and is broken down through metabolism to produce energy. Hormones and enzymes produced by the liver and pancreas control this process. The hormone insulin, produced by the pancreas, regulates blood glucose levels. When these levels are high, such as after a meal, insulin is secreted to transport glucose into cells for energy production. Elevated glucose levels in the body after fasting may indicate a risk of developing prediabetes or diabetes, which can be of two types- Type 1, caused by little or no insulin production, and Type 2, caused by insulin resistance or decreased insulin production.

Know more about FBS (Fasting Blood Sugar)

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VDRL-RPR (Rapid Plasma Reagin)

The VDRL-RPR (Rapid Plasma Reagin) test looks for antibodies (specific proteins) that react to syphilis in the blood. This means the test doesn't find the actual bacteria that cause syphilis. Instead, it looks for antibodies against substances given off by cells that have been harmed by the bacteria.  Antibodies are a specific type of protein produced by your immune system to fight off any invaders, such as bacteria, viruses, or toxins. Detecting these antibodies can help your doctors know if you have syphilis. Untreated syphilis can spread to your eyes, blood vessels, heart, and brain. But it can be easily cured if treated in the early stages.

Know more about VDRL-RPR (Rapid Plasma Reagin)

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TSH (Thyroid Stimulating Hormone) Ultrasensitive

The TSH (Thyroid Stimulating Hormone) Ultrasensitive test measures the levels of TSH hormone in the blood. TSH is produced by the pituitary gland located in the brain. Its function is to stimulate and regulate the functioning of the thyroid gland. It signals the thyroid gland to increase or decrease the production of thyroid hormones T3 and T4 (essential for regulating our body’s metabolism, temperature, heart rate, and growth) when their levels are low or high, respectively. Therefore, when the levels of T3 & T4 decrease, the pituitary gland is stimulated to release TSH. This high TSH level, in turn, stimulates the thyroid gland to release more thyroid hormones (T3 & T4); the vice-versa happens when the levels of thyroid hormones increase.

Know more about TSH (Thyroid Stimulating Hormone) Ultrasensitive

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Blood Group ABO & RH Factor Test

The Blood Group ABO & RH Factor Test determines your blood type and Rh factor. Healthcare providers can ensure compatibility and prevent adverse reactions during medical interventions by identifying an individual's blood type and Rh factor. This test is essential for various medical procedures, including blood transfusions, organ transplants, and prenatal care.

Know more about Blood Group ABO & RH Factor Test

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HIV Combo (Antigen And Antibody) Test

An HIV Combo (Antigen And Antibody) Test simultaneously detects HIV p24 antigen and antibodies associated with HIV 1 & 2. The HIV p24 antigen is the most abundant HIV protein and its detection is used clinically to diagnose an HIV infection early on since HIV-specific antibodies are not detectable in a very recently acquired infection. HIV-1 was discovered first and is the most widespread, whereas HIV-2 is more than 55% genetically different from HIV-1. The transmission rate of HIV-2 is also slower than HIV-1. 

Know more about HIV Combo (Antigen And Antibody) Test

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Urine R/M (Urine Routine & Microscopy)

The Urine R/M (Urine Routine & Microscopy) test involves gross, chemical, and microscopic evaluation of the urine sample.

  1. Gross examination: It involves visually inspecting the urine sample for color and appearance. Typically, the urine color ranges from colorless or pale yellow to deep amber, depending on the urine’s concentration. Things such as medications, supplements, and some foods such as beetroot can affect the color of your urine. However, unusual urine color can also be a sign of disease.

    In appearance, the urine sample may be clear or cloudy. A clear appearance is indicative of healthy urine. However, the presence of red blood cells, white blood cells, bacteria, etc., may result in cloudy urine, indicating conditions such as dehydration, UTIs, kidney stones, etc. Some other factors, such as sperm and skin cells, may also result in a cloudy appearance but are harmless.

  2. Chemical examination: It examines the chemical nature of the urine sample using special test strips called dipsticks. These test strips are dipped into the urine sample and change color when they come in contact with specific substances. The degree of color change estimates the amount of the substance present. Some common things detected include protein, urine pH, ketones, glucose, specific gravity, blood, bilirubin, nitrites, and urobilinogen.

  3. Microscopic examination: This involves the analysis of the urine sample under the microscope for pus cells, red blood cells, casts, crystals, bacteria, yeast. and other constituents.

Know more about Urine R/M (Urine Routine & Microscopy)

  • Urobilinogen

  • The Urobilinogen test measures the amount of urobilinogen present in the urine. Urobilinogen is a substance formed from the breakdown of bilirubin, a by-product of old red blood cells processed by the liver. This test plays a key role in assessing liver function and detecting liver diseases.

    Under normal circumstances, the liver converts bilirubin into urobilinogen. Some of this urobilinogen is reabsorbed into the blood, excreted by the kidneys, and then eliminated from the body through urine. However, when liver function is impaired, the amount of urobilinogen in the urine can change. Hence, the Urobilinogen test serves as an important indicator of abnormalities such as liver disease or blockage of the bile ducts.

  • Ketone

  • The Ketone test measures the presence of ketone bodies in the urine, which are metabolic byproducts produced when the body breaks down fat for energy in the absence of sufficient carbohydrates. This process, known as ketosis, typically occurs during states such as prolonged fasting, strict low-carbohydrate diets, or in certain medical conditions like uncontrolled diabetes mellitus, particularly type 1 diabetes. In diabetes, for instance, the test can help identify diabetic ketoacidosis (DKA), a serious complication characterized by high levels of ketones that can lead to an acid-base imbalance in the blood. The presence of ketones in the urine can be an important marker for monitoring metabolic states and managing conditions that affect blood sugar levels.

  • Nitrite

  • The Nitrite test measures the presence of nitrites in the urine sample. Nitrites are chemicals formed by the conversion of nitrates by certain bacteria. Under normal conditions, urine does not contain nitrites. However, when bacteria that cause urinary tract infections (UTIs) are present, they convert nitrates (which are normally found in the urine) into nitrites. Thus, the presence of nitrites in urine is an indication of a bacterial infection, making the Nitrite test a key tool in diagnosing UTIs.

  • Colour

  • The urine colour test primarily measures the concentration and colour of urine to provide insights into an individual’s  overall health. It assesses hydration status, with clear to light yellow urine indicating good hydration and darker shades suggesting dehydration. It can also detect urinary tract infections (UTIs) through unusual colours like cloudy or reddish urine, signaling the presence of blood or pus. Abnormal urine colours, such as dark brown or amber, may indicate liver conditions like hepatitis or cirrhosis, while pink, red, or brown urine can reveal the presence of blood, signaling kidney issues, trauma, or potential malignancies. The test can reflect dietary influences and supplement intake, with certain foods and vitamins causing colour changes. It can also highlight metabolic disorders, such as porphyria, which may cause purple urine. Additionally, medication effects and potential exposure to toxins can be inferred from changes in urine colour, making this test a comprehensive indicator of overall health and potential underlying conditions.

  • Appearance

  • The urine appearance test measures:

    Colour: The urine colour indicates the presence of substances like bilirubin, blood, or medications in the urine, providing clues about liver function, hydration levels, or underlying health issues.

    Clarity: The urine clarity assesses the transparency of urine, which can reveal the presence of cells, proteins, or other particles that may indicate infections or kidney disease.

    Odor: The urine odor detects abnormal smells that may indicate infections or metabolic disorders affecting the urinary system.

    By examining these aspects, doctors can gain insights into hydration status, kidney function, and potential health conditions affecting the urinary tract. This comprehensive evaluation aids in timely diagnosis and management of potential urinary tract problems. 

  • Specific Gravity

  • The urine Specific Gravity test measures the concentration of solutes in the urine, reflecting the kidneys' ability to concentrate or dilute the urine in response to varying hydration levels. By comparing the density of urine to that of water, the test provides insights into the balance of fluids and substances like salts, waste products, and other solutes. This test is important because it helps diagnose and monitor various medical conditions, including dehydration, kidney disease, diabetes insipidus, and other disorders affecting kidney function, enabling timely and appropriate medical interventions.

  • Pus Cell

  • The pus cells test measures the presence and quantity of pus cells in urine samples. This test helps identify urinary tract infections (UTIs) and other inflammatory conditions of the urinary tract. Doctors perform this test to promptly diagnose and manage urinary tract-related disorders, ensuring timely treatment and management.

  • Epithelial Cell

  • The Epithelial Cell test measures the presence and quantity of epithelial cells shed into the urine. This test helps doctors understand urinary tract health by identifying abnormalities such as infections, inflammation, or damage to kidney tubules. Different types of epithelial cells in urine, including squamous, transitional, and renal tubular epithelial cells, provide specific insights into the nature and location of urinary tract issues. This test aids in diagnosing conditions affecting the urinary system and guides appropriate treatment strategies based on the findings.

  • Casts

  • The urinary cast test measures the presence, and quantity of casts in a urine sample. These casts are cylindrical structures formed from coagulated proteins and cells within the kidney's tubules. By identifying and quantifying the different types of casts, such as red blood cell casts, white blood cell casts, granular casts, and hyaline casts, the test provides valuable insights into kidney health. The presence of specific types of casts can indicate underlying kidney conditions, such as glomerulonephritis, kidney infections, acute tubular necrosis, and chronic kidney disease. This test helps doctors diagnose, monitor, and manage kidney-related issues, guiding appropriate medical interventions and treatments.

  • Crystals

  • The Crystals test measures the presence, type, and quantity of crystals in a urine sample. Crystals can form from various salts and minerals in the urine, and their identification helps diagnose underlying conditions such as kidney stones, urinary tract infections, or metabolic disorders. The test provides insights into potential urinary tract issues by detecting specific types of crystals, such as calcium oxalate, uric acid, or struvite crystals. By analyzing the crystals, doctors can determine the severity of the condition, monitor the effectiveness of treatment, and guide preventive measures to maintain optimal urinary tract health.

  • Protein Urine

  • The Protein Urine test detects the presence of proteins in the urine sample. Essential proteins are typically retained in the blood by healthy kidneys, but their presence in urine can indicate kidney damage or dysfunction. Conditions like diabetes, hypertension, and certain kidney diseases can cause increased protein leakage into the urine. This test is crucial for assessing kidney health and detecting abnormalities that may require further investigation or intervention.

  • Ph for Urine

  • The Ph for Urine primarily measures the acidity or alkalinity of urine by assessing the balance of hydrogen ions in the urine. It provides insights into an individual’s metabolic and kidney function, with acidic urine suggesting conditions like metabolic or respiratory acidosis, and alkaline urine indicating potential metabolic or respiratory alkalosis. The test can also reflect dietary influences, such as high protein diets may lead to acidic urine, while fruit-rich diets may result in alkaline urine. Abnormal pH levels can indicate conditions such as urinary tract infections, kidney stones, and certain metabolic disorders. Additionally, the test helps to monitor the impact of medications and supplements on urine pH, making it a valuable tool for comprehensive health assessment and diagnosis.

  • Urine Glucose

  • The Urine Glucose test measures the presence or absence of glucose in the urine sample. Normally, glucose is filtered out by the kidneys and reabsorbed into the blood, so it should not be detectable in the urine. When glucose appears in the urine, it indicates that blood glucose levels may be elevated beyond the kidneys' reabsorption capacity. 

    Urine glucose is a useful test to check how well your body is managing glucose levels and kidney function. It helps diagnose and monitor diabetes, provides insight into blood sugar control, and can indicate potential issues with kidney function.

  • Yeast

  • The urine yeast test measures the presence of yeast cells in the urine sample. The presence of yeast cells can indicate an infection or an imbalance in the urinary tract's natural microbial environment. Yeast is a type of fungus that naturally resides in small amounts on the skin, in the mouth, and in the intestines. However, when it overgrows, it can cause infections, such as yeast infections in the urinary tract which require medical attention. Therefore this test is crucial for identifying fungal infections, particularly those caused by Candida species, and plays a vital role in guiding appropriate treatment strategies.

  • Red Blood Cells

  • The Red Blood Cells test measures the presence and amount of red blood cells (RBCs) in a urine sample. The primary purpose of the test is to detect hematuria, a condition characterized by the presence of blood in the urine. Hematuria can be either visible (gross hematuria) or invisible to the naked eye (microscopic hematuria), and the RBC Urine Test is capable of detecting both. It serves as an early indicator of various underlying health conditions ranging from urinary tract infections (UTIs), kidney stones, and kidney disease, to more serious conditions such as bladder cancer or trauma to the urinary tract. Early identification of hematuria through the RBC Urine Test can prompt timely treatment and management of these conditions, which can significantly improve patient outcomes and prevent complications. 

  • Leucocyte Esterase

  • The Leucocyte Esterase test measures the presence of leukocyte esterase (an enzyme released by white blood cells) in urine samples, which are typically present when there is an infection or inflammation in the urinary tract. Common conditions associated with elevated leukocyte esterase levels include urinary tract infections (UTIs), kidney infections (pyelonephritis), and interstitial cystitis. When the body's immune system detects pathogens such as bacteria, it sends white blood cells to the affected area to combat the infection, leading to an increase in leukocyte esterase levels in the urine. Thus, the Leucocyte Esterase test serves as a marker for these underlying issues ensuring early detection and appropriate treatment.

  • Blood

  • The Blood test measures the presence of blood in the urine sample, indicating potential issues within the urinary system or kidneys. This test is crucial for diagnosing conditions such as hematuria,  urinary tract infections (UTIs), kidney stones, kidney disease, or even certain cancers that can cause bleeding in the urinary tract.

    Depending on whether the blood is visible to the naked eye (macroscopic hematuria) or only detectable under a microscope (microscopic hematuria), doctors can assess the severity and potential causes of the bleeding. By analyzing the presence of blood in the urine sample, doctors can determine the appropriate course of treatment and management, ensuring timely intervention to address underlying health concerns affecting urinary tract and kidney function.

  • Bacteria

  • The Bacteria test measures the presence and amount of bacteria in the urine. Normally, urine is sterile, but the presence of bacteria indicates an infection in the urinary system. This test helps diagnose UTIs, bladder infections, and other related conditions, guiding appropriate treatment plans.

  • Bilirubin

  • The Bilirubin test measures the levels of bilirubin present in the urine. Bilirubin is a by-product of the breakdown of old red blood cells, processed by the liver. This test is crucial in assessing liver function and detecting liver diseases.

    Normally, the liver converts bilirubin into a form that can be excreted into bile and eventually eliminated from the body. When liver function is impaired, the amount of bilirubin in the urine can change, serving as an important indicator of abnormalities such as liver disease or bile duct blockage.

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Hepatitis B Surface Antigen (HBsAg)

The Hepatitis B Surface Antigen (HBsAg) test detects the presence of a specific protein on the surface of the Hepatitis B virus (HBV) in the bloodstream. This protein, HBsAg, serves as a crucial marker for identifying HBV infection. This is a screening test and the diagnosis of any reactive HBsAg result relies on additional supplemental tests like anti-HBs antibody and total anti-HBc antibodies. Confirmation can be done using nucleic acid tests like HBV DNA by PCR. The Hepatitis B Surface Antigen (HBsAg) test is essential for identifying individuals who require medical intervention, such as antiviral therapy, and for implementing measures to prevent the spread of Hepatitis B virus to others. 

Know more about Hepatitis B Surface Antigen (HBsAg)

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about Antenatal Profile


Frequently Asked Questions about Antenatal Profile

Q. What is an Antenatal Profile?

An Antenatal Profile is a comprehensive set of blood and urine tests recommended for pregnant women, particularly during the first trimester. It helps detect maternal conditions that may affect the development of the baby and assesses the risk of infections that can be transmitted from the mother to the baby.

Q. Why is an Antenatal Profile important during pregnancy?

An Antenatal Profile is important during pregnancy as it helps minimize pregnancy associated complications, safeguard the health of both the mother and the baby, and allows for timely interventions if any abnormalities are detected.

Q. What are the key components of an Antenatal Profile?

Key components of an Antenatal Profile include CBC (Complete Blood Count) test, urine test, blood Group ABO & RH factor test, TSH test, fasting blood sugar test, and tests to detect infections like HIV, and syphilis.

Q. Is prenatal testing necessary even if I feel healthy?

Yes, prenatal testing is necessary even if you feel healthy because it helps detect any potential health risks or complications that may affect the pregnancy and the health of the baby. Early detection through prenatal testing allows for timely interventions and proper management of any identified issues, ensuring a healthy pregnancy and safe delivery.

Q. Is it safe to take an Antenatal Profile?

Yes, it is safe to take an antenatal profile test during pregnancy. These tests are specifically tailored to monitor the health of both the mother and developing baby, and they are routinely recommended by doctors to ensure a healthy pregnancy and delivery.

Q. Why do I need an Antenatal Profile?

You may need an Antenatal Profile to monitor your health and the health of your baby during pregnancy. These tests help detect any potential pregnancy- related complications early on, allowing for timely intervention and management to ensure a safe and healthy pregnancy for both you and your baby.

Q. In what conditions my doctor may suggest an Antenatal Profile?

Doctors may suggest an Antenatal Profile during the first trimester of pregnancy as this test can help identify pre-existing medical conditions or health concerns like anemia, diabetes, etc in the early stages of pregnancy.

Q. How often should I expect to undergo an Antenatal Profile testing during my pregnancy?

The testing frequency can vary, with some tests performed during the first trimester and others at later stages. Your doctor will guide you more comprehensively based on your specific health needs.
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References

  1. Antenatal checks and tests [Internet]. NHS; 30 Nov. 2020 [Accessed 12 Mar. 2024]. Available from: https://www.nhs.uk/pregnancy/your-pregnancy-care/antenatal-checks-and-tests/ External Link
  2. Aksoy S. Antenatal screening and its possible meaning from unborn baby's perspective. BMC Med Ethics. 2001;2:E3. [Accessed 12 Mar. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC32195/ External Link
  3. Genetic Alliance; The New York-Mid-Atlantic Consortium for Genetic and Newborn Screening Services. Understanding Genetics: A New York, Mid-Atlantic Guide for Patients and Health Professionals. Washington (DC): Genetic Alliance; 2009 Jul 8. APPENDIX H, PRENATAL SCREENING AND TESTING. [Accessed 12 Mar. 2024]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK115544/ External Link
  4. Ala SH, Husain S, Husain S. Reasons for presenting to antenatal care clinics in a sample of Pakistani women and their knowledge of WHO antenatal care package. Eur J Midwifery. 2021 Oct 1;5:43. [Accessed 12 Mar. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486015/ External Link
  5. Pregnancy, Childbirth, Postpartum and Newborn Care: A Guide for Essential Practice. 3rd edition. Geneva: World Health Organization; 2015. C, ANTENATAL CARE. [Accessed 12 Mar. 2024]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK326665/ External Link
  6. Know your terms [Internet]. NIH; 06 Feb. 2022. [Accessed 12 Mar. 2024]. Available from: https://www.nichd.nih.gov/ncmhep/initiatives/know-your-terms/moms External Link
  7. Health tips for pregnant women [Internet]. NIH; Oct. 2019. [Accessed 12 Mar. 2024]. Available from: https://www.niddk.nih.gov/health-information/weight-management/healthy-eating-physical-activity-for-life/health-tips-for-pregnant-women#:~:text=take%20while%20pregnantExternal Link

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